Calculating the ASCVD Risk Estimator Plus score

This vignette assumes a SQL server at localhost (we use PostgreSQL), with data in OMOP Common Data Model v5.4 format in schema cdm_new_york3. The patient records shown in this example are synthetic data from Synthea(TM) Patient Generator.

The Atherosclerotic cardiovascular disease (ASCVD) events Risk Estimator+ (ASCVD Risk Estimator Plus, or ASCVD+ for short) is a score developed by the American College of Cardiology/American Heart Association Task Force on Practice Guidelines for assessing the 10-year risk of an event. It was published in 12 Nov 2013 at (https://doi.org/10.1161/01.cir.0000437741.48606.98)[https://doi.org/10.1161/01.cir.0000437741.48606.98].

To get a sense of what goes into the score, one can look at the calculator provided by the American College of Cardiology:

The mathematical formula for the score is a bit complicated and is shown further down in this vignette.

To compute this phenotype, we first prepare the components, then the formula parts, then we put it all together in calculate_formula().

Components

Systolic Blood Pressure (mm Hg)

3004249 Loinc 8480-6 Systolic blood pressure

sbp <- sqlt(measurement) |>
  filter(measurement_concept_id == 3004249) |>
  make_component(
    .pid = person_id,
    .ts = measurement_datetime)

Diastolic Blood Pressure (mm Hg)

3012888 Loinc 8462-4 Diastolic blood pressure

dbp <- sqlt(measurement) |>
  filter(measurement_concept_id == 3012888) |>
  make_component(
    .pid = person_id,
    .ts = measurement_datetime)

Total Cholesterol (mg/dL)

3027114 Loinc 2093-3 Cholesterol [Mass/volume] in Serum or Plasma

tc <- sqlt(measurement) |>
  filter(measurement_concept_id == 3027114) |>
  make_component(
    .pid = person_id,
    .ts = measurement_datetime)

HDL Cholesterol (mg/dL)

3007070 Loinc 2085-9 Cholesterol in HDL [Mass/volume] in Serum or Plasma

hdl <- sqlt(measurement) |>
  filter(measurement_concept_id == 3007070) |>
  make_component(
    .pid = person_id,
    .ts = measurement_datetime)

LDL Cholesterol (mg/dL)

3009966 Loinc 18262-6 Cholesterol in LDL [Mass/volume] in Serum or Plasma by Direct assay

ldl <- sqlt(measurement) |>
  filter(measurement_concept_id == 3009966) |>
  make_component(
    .pid = person_id,
    .ts = measurement_datetime)

History of Diabetes?

201826 SNOMED 44054006 Type 2 diabetes mellitus

diabetes <- sqlt(condition_occurrence) |>
  filter(condition_concept_id == 201826) |>
  make_component(
    .pid = person_id,
    .ts = condition_start_datetime)

Smoker?

43054909 LOINC 72166-2 Tobacco smoking status [Not required] 42709996 SNOMED 449868002 Smokes tobacco daily

smoker <- sqlt(observation) |>
  filter(observation_concept_id %in% c(42709996)) |>
  make_component(
    .pid = person_id,
    .ts = observation_datetime)

On Hypertension Treatment?

ATC:

C02 ANTIHYPERTENSIVES
C03 - Diuretics
C07 - Beta blocking agents
C08 - Calcium channel blockers and
C09 - Agents acting on the renin-angiotensin system.

atc_concepts <- sqlt(concept) |>
  filter(concept_code %in% c('C02', 'C03', 'C07', 'C08', 'C09') &&
      vocabulary_id == 'ATC') |>
  select(concept_id)

drug_concepts <- sqlt(concept_ancestor) |>
  inner_join(atc_concepts, by = c('ancestor_concept_id' = 'concept_id')) |>
  select(descendant_concept_id)

htt <- sqlt(drug_exposure) |>
  inner_join(drug_concepts, by = c('drug_concept_id' = 'descendant_concept_id')) |>
  make_component(
    .pid = person_id,
    .ts = drug_exposure_start_datetime)

On a Statin?

[Not required]

On Aspirin Therapy?

[Not required]

Patient age

person <- sqlt(person) |>
  make_component(
    .pid = person_id,
    .ts = birth_datetime)

Formula

The ASCVD Risk Estimator+ formula can be a bit abstruse at first. Here’s how the original paper phrased it: There are a three main parts here:

The individual sum
The survival baseline
The group mean

The truth is, the formula as written over there is slightly wrong. By checking the numbers from the paper, one can realize that the ASCVD+ formula is:

(1-b) * exp(a-c)

We prepare each part a, b and c separately, then assemble them together in calculate_formula().

The individual sum comes from multiplying the values of the components by their coefficients as published in Table A.:

Notice that the formula has 4 variations, according to whether the patient:

Is a woman or man
Is white or not

We use CASE WHEN ... constructs to prepare the formula according to these 4 groups.

Individual sum

Let us first compute the individual sum using the coeficients according to each of the 4 groups.

# WHITE WOMEN
white_women_sum <- paste(sep = ' + ',
  '-29.799 * ln(age)', # Ln Age (y) –29.799
  
  '4.884 * ln(age)^2', # Ln Age, Squared 4.884
  
  '13.540 * ln(tc_value_as_number)', # Ln Total Cholesterol (mg/dL) 13.540

  '-3.114 * ln(age) * ln(tc_value_as_number)', # Ln Age × Ln Total Cholesterol –3.114
  
  '-13.578 * ln(hdl_value_as_number)', # Ln HDL-C (mg/dL) –13.578
  
  '3.149 * ln(age) * ln(hdl_value_as_number)', # Ln Age × Ln HDL-C 3.149
  
  'case when htt is true then
    2.019 * ln(sbp_value_as_number) else 0 end', # Ln Treated Systolic BP (mm Hg) 2.019
  
  ### # Ln Age × Ln Treated Systolic BP N/A
  
  'case when htt is false then
    1.957 * ln(sbp_value_as_number) else 0 end', # Ln Untreated Systolic BP (mm Hg) 1.957
  
  ### # Ln Age × Ln Untreated Systolic BP N/A
  
  '7.574 * case when is_smoker then 1 else 0 end', # Current Smoker (1=Yes, 0=No) 7.574
  
  '-1.665 * ln(age) * case when is_smoker then 1 else 0 end', # Ln Age × Current Smoker –1.665
  
  '0.661 * case when has_diabetes then 1 else 0 end' # Diabetes (1=Yes, 0=No) 0.661
)

# BLACK WOMEN
black_women_sum <- paste(sep = ' + ',
  # Ln Age (y) 17.114
  '17.114 * ln(age)',
  
  # Ln Age, Squared N/A
  
  # Ln Total Cholesterol (mg/dL) 0.940
  '0.940 * ln(tc_value_as_number)',
  
  # Ln Age × Ln Total Cholesterol N/A
  
  # Ln HDL-C (mg/dL) –18.920
  '-18.920 * ln(hdl_value_as_number)',
  
  # Ln Age × Ln HDL-C 4.475
  '4.475 * ln(age) * ln(hdl_value_as_number)',
  
  # Ln Treated Systolic BP (mm Hg) 29.291
  'case when htt is true then
    29.291 * ln(sbp_value_as_number) else 0 end',
  
  # Ln Age × Ln Treated Systolic BP –6.432
  'case when htt is true then
    -6.432 * ln(age) * ln(sbp_value_as_number) else 0 end',
  
  # Ln Untreated Systolic BP (mm Hg) 27.820
  'case when htt is false then
    27.820 * ln(sbp_value_as_number) else 0 end',
  
  # Ln Age × Ln Untreated Systolic BP –6.087
  'case when htt is false then
    -6.087 * ln(age) * ln(sbp_value_as_number) else 0 end',
  
  # Current Smoker (1=Yes, 0=No) 0.691
  '0.691 * case when is_smoker then 1 else 0 end',
  
  # Ln Age × Current Smoker N/A
  
  # Diabetes (1=Yes, 0=No) 0.874
  '0.874 * case when has_diabetes then 1 else 0 end'
  )

# WHITE MEN
white_men_sum <- paste(sep = ' + ',
  # Ln Age (y) 12.344
  '12.344 * ln(age)',
  
  # Ln Total Cholesterol (mg/dL) 11.853
  '11.853 * ln(tc_value_as_number)',
  
  # Ln Age × Ln Total Cholesterol –2.664
  '-2.664 * ln(age) * ln(tc_value_as_number)',
  
  # Ln HDL-C (mg/dL) –7.990
  '-7.990 * ln(hdl_value_as_number)',
  
  # Ln Age × Ln HDL-C 1.769
  '1.769 * ln(age) * ln(hdl_value_as_number)',
  
  # Ln Treated Systolic BP (mm Hg) 1.797
  'case when htt is true then 
    1.797 * ln(sbp_value_as_number) else 0 end',
  
  # Ln Untreated Systolic BP (mm Hg) 1.764
  'case when htt is false then
    1.764 * ln(sbp_value_as_number) else 0 end',
  
  # Current Smoker (1=Yes, 0=No) 7.837
  '7.837 * case when is_smoker then 1 else 0 end',
  
  # Ln Age × Current Smoker –1.795
  '-1.795 * ln(age) * case when is_smoker then 1 else 0 end',
  
  # Diabetes (1=Yes, 0=No) 0.658
  '0.658 * case when has_diabetes then 1 else 0 end'
)

# BLACK MEN
black_men_sum <- paste(sep = ' + ',
  # Ln Age (y) 2.469
  '2.469 * ln(age)',
  
  # Ln Total Cholesterol (mg/dL) 0.30
  '0.30 * ln(tc_value_as_number)',
  
  # Ln Age × Ln Total Cholesterol N/A
  
  # Ln HDL-C (mg/dL) –0.307
  '-0.307 * ln(hdl_value_as_number)',
  
  # Ln Age × Ln HDL-C N/A
  
  # Ln Treated Systolic BP (mm Hg) 1.916
  'case when htt is true then
    1.916 * ln(sbp_value_as_number) else 0 end',
  
  # Ln Untreated Systolic BP (mm Hg) 1.809
  'case when htt is false then
    1.809 * ln(sbp_value_as_number) else 0 end',
  
  # Current Smoker (1=Yes, 0=No) 0.549
  '0.549 * case when is_smoker then 1 else 0 end',
  
  # Ln Age × Current Smoker N/A
  
  # Diabetes (1=Yes, 0=No) 0.645
  '0.645 * case when has_diabetes then 1 else 0 end'
  )

Formula parts

To facilitate reading and using the code, we assemble parts of the phenotype in separate formulas.

individual_sum <- paste0(
  'case when is_woman then (
    case when is_black then (', black_women_sum, ')
    else (', white_women_sum, ')
    end)
  else (
    case when is_black then (', black_men_sum, ')
    else (', white_men_sum, ')
    end)
  end')

baseline_survival <- paste0(
  'case when is_woman then (
    case when is_black then 0.9533
    else 0.9665
    end)
  else (
    case when is_black then 0.8954
    else 0.9144
    end)
  end')

group_mean <- paste0(
  'case when is_woman then (
    case when is_black then 86.61
    else -29.18
    end)
  else (
    case when is_black then 19.54
    else 61.18
    end)
  end')

Calculate formula

Armed with the components and formula parts, we put it all together in calculate_formula().

ascvd = calculate_formula(
  components = list(
    sbp = sbp,
    dbp = dbp,
    tc = tc,
    hdl = hdl,
    ldl = ldl,
    diabetes = diabetes,
    smoker = smoker,
    htt = htt,
    person = person),
  export = c(
    'sbp_value_as_number',
    # 'dbp_value_as_number',
    'tc_value_as_number',
    'hdl_value_as_number',
    # 'ldl_value_as_number',
    'diabetes_condition_concept_id',
    'diabetes_condition_start_datetime',
    'smoker_observation_datetime',
    'htt_drug_concept_id',
    'htt_drug_exposure_start_datetime',
    'person_birth_datetime'),
  fml = list(
    preprocess = list(
      is_woman = 'person_gender_concept_id = 8532',
      
      is_black = 'person_race_concept_id = 8516',
      
      age = 'extract(year from age(ts, person_birth_datetime))',
      
      is_smoker = 'smoker_observation_datetime is null',
      
      has_diabetes = 'diabetes_condition_start_datetime is null',
      
      htt_sbp_dist = "case when htt_drug_exposure_start_datetime - sbp_measurement_datetime < interval '0'
        then sbp_measurement_datetime - htt_drug_exposure_start_datetime
        else htt_drug_exposure_start_datetime - sbp_measurement_datetime end"
    ),

    htt = "htt_drug_exposure_start_datetime is not null
      and htt_sbp_dist < '4 months'", # SBP and HTT within 4 months of each other
    
    individual_sum = individual_sum,
    
    baseline_survival = baseline_survival,
    
    group_mean = group_mean,
    
    calculated_risk = '(1 - baseline_survival) * exp(individual_sum - group_mean)',
    
    estimated_risk = 'least(0.3, greatest(0.01, calculated_risk))' # Cap to 1%-30%.
    ),
  
  .dont_require = c('smoker', 'htt', 'diabetes'),
  
  .out_window = c('person', 'diabetes'))

Results

Let us peek at 20 rows from the phenotype.

ascvd |>
  head_shot(20, blind = TRUE) |>
  kable()

row_id	pid	ts	window	person_gender_concept_id	person_race_concept_id	person_birth_datetime	smoker_observation_datetime	diabetes_condition_start_datetime	htt_drug_exposure_start_datetime	sbp_measurement_datetime	tc_value_as_number	hdl_value_as_number	sbp_value_as_number	diabetes_condition_concept_id	htt_drug_concept_id	is_woman	is_black	age	is_smoker	has_diabetes	htt_sbp_dist	htt	individual_sum	baseline_survival	group_mean	calculated_risk	estimated_risk
21	1	2005-05-13	00:00:00	8507	8527	1974-03-01	NA	NA	NA	2005-05-13	199.0	79.1	121	NA	NA	FALSE	FALSE	31	TRUE	TRUE	NA	FALSE	59.12642	0.9144	61.18	0.0109803	0.0109803
41	1	2006-05-12	364 days	8507	8527	1974-03-01	NA	NA	NA	2006-05-12	199.0	79.1	121	NA	NA	FALSE	FALSE	32	TRUE	TRUE	NA	FALSE	59.25911	0.9144	61.18	0.0125384	0.0125384
42	1	2008-05-16	00:00:00	8507	8527	1974-03-01	NA	NA	NA	2008-05-16	182.2	73.8	117	NA	NA	FALSE	FALSE	34	TRUE	TRUE	NA	FALSE	59.35782	0.9144	61.18	0.0138392	0.0138392
23	1	2011-05-20	00:00:00	8507	8527	1974-03-01	NA	2011-05-20	NA	2011-05-20	183.1	60.7	134	201826	NA	FALSE	FALSE	37	TRUE	FALSE	NA	FALSE	59.62615	0.9144	61.18	0.0180986	0.0180986
14	1	2014-03-07	00:00:00	8507	8527	1974-03-01	NA	2011-05-20	NA	2014-03-07	209.9	43.5	108	201826	NA	FALSE	FALSE	40	TRUE	FALSE	NA	FALSE	60.31688	0.9144	61.18	0.0361099	0.0361099
45	1	2016-03-11	00:00:00	8507	8527	1974-03-01	NA	2011-05-20	NA	2016-03-11	224.1	57.3	123	201826	NA	FALSE	FALSE	42	TRUE	FALSE	NA	FALSE	60.43606	0.9144	61.18	0.0406805	0.0406805
26	1	2018-03-16	00:00:00	8507	8527	1974-03-01	NA	2011-05-20	NA	2018-03-16	221.5	52.7	111	201826	NA	FALSE	FALSE	44	TRUE	FALSE	NA	FALSE	60.49591	0.9144	61.18	0.0431896	0.0431896
47	1	2020-03-20	00:00:00	8507	8527	1974-03-01	NA	2011-05-20	NA	2020-03-20	205.0	55.5	127	201826	NA	FALSE	FALSE	46	TRUE	FALSE	NA	FALSE	60.68360	0.9144	61.18	0.0521065	0.0521065
48	1	2022-02-11	00:00:00	8507	8527	1974-03-01	NA	2011-05-20	NA	2022-02-11	212.2	46.6	130	201826	NA	FALSE	FALSE	47	TRUE	FALSE	NA	FALSE	61.06067	0.9144	61.18	0.0759716	0.0759716
29	1	2022-03-25	00:00:00	8507	8527	1974-03-01	NA	2011-05-20	NA	2022-03-25	204.0	51.4	109	201826	NA	FALSE	FALSE	48	TRUE	FALSE	NA	FALSE	60.64193	0.9144	61.18	0.0499794	0.0499794
152	2	2004-07-17	00:00:00	8507	8527	1949-10-29	NA	NA	2004-07-17	2004-07-17	199.8	61.4	178	NA	19073094	FALSE	FALSE	54	TRUE	TRUE	00:00:00	TRUE	62.53925	0.9144	61.18	0.3332655	0.3000000
106	2	2005-07-23	371 days	8507	8527	1949-10-29	NA	NA	2005-07-23	2005-07-23	199.8	61.4	151	NA	19073094	FALSE	FALSE	55	TRUE	TRUE	00:00:00	TRUE	62.31191	0.9144	61.18	0.2654953	0.2654953
107	2	2006-07-29	742 days	8507	8527	1949-10-29	NA	NA	2006-07-29	2006-07-29	199.8	61.4	157	NA	19073094	FALSE	FALSE	56	TRUE	TRUE	00:00:00	TRUE	62.44897	0.9144	61.18	0.3044964	0.3000000
155	2	2007-08-04	00:00:00	8507	8527	1949-10-29	NA	NA	2007-08-04	2007-08-04	186.4	71.2	148	NA	19073094	FALSE	FALSE	57	TRUE	TRUE	00:00:00	TRUE	62.20954	0.9144	61.18	0.2396606	0.2396606
156	2	2008-08-09	371 days	8507	8527	1949-10-29	NA	NA	2008-08-09	2008-08-09	186.4	71.2	171	NA	19073094	FALSE	FALSE	58	TRUE	TRUE	00:00:00	TRUE	62.54160	0.9144	61.18	0.3340476	0.3000000
110	2	2009-08-15	742 days	8507	8527	1949-10-29	NA	NA	2009-08-15	2009-08-15	186.4	71.2	142	NA	19073094	FALSE	FALSE	59	TRUE	TRUE	00:00:00	TRUE	62.27889	0.9144	61.18	0.2568718	0.2568718
52	2	2010-08-21	00:00:00	8507	8527	1949-10-29	NA	NA	2010-08-21	2010-08-21	173.6	60.4	182	NA	19073094	FALSE	FALSE	60	TRUE	TRUE	00:00:00	TRUE	62.85054	0.9144	61.18	0.4549675	0.3000000
159	2	2011-08-27	371 days	8507	8527	1949-10-29	NA	NA	2011-08-27	2011-08-27	173.6	60.4	185	NA	19073094	FALSE	FALSE	61	TRUE	TRUE	00:00:00	TRUE	62.94713	0.9144	61.18	0.5011044	0.3000000
113	2	2012-09-01	742 days	8507	8527	1949-10-29	NA	NA	2012-09-01	2012-09-01	173.6	60.4	155	NA	19073094	FALSE	FALSE	62	TRUE	TRUE	00:00:00	TRUE	62.69530	0.9144	61.18	0.3895477	0.3000000
114	2	2013-09-07	00:00:00	8507	8527	1949-10-29	NA	NA	2013-09-07	2013-09-07	176.2	77.5	150	NA	19073094	FALSE	FALSE	63	TRUE	TRUE	00:00:00	TRUE	62.54883	0.9144	61.18	0.3364732	0.3000000

Plots

To make a visually interesting plot, let us pick a patient at random, but from among those that have the most data points.

patients_with_most_data <- list(ascvd = ascvd) |>
  sqla('
    select pid, count(*) as rows
    from ascvd
    group by pid
    order by rows desc
    limit 20
    ') |>
  pull('pid')

#> 12/03 15:19 Reading 'patients_with_most_data' from '../sai/rds/patients_with_most_data.qs'.

From the 20 patients_with_most_data, we pick one at random.

random_patient <- sample(patients_with_most_data, 1)

message('Sampled patient: ', random_patient)
#> Sampled patient: 18983

And then we plot the chosen patient.

ascvd |>
  select(-ends_with('datetime'), -ends_with('concept_id'), -htt_sbp_dist,
    -group_mean, -individual_sum, -calculated_risk, -baseline_survival) |>
  phea_plot(random_patient, verbose = FALSE)

Obtain the SQL query that computes the phenotype

To see the SQL query that computes the phenotype, use helper function code_shot(), or dbplyr::sql_render(), or the .clip_sql option in calculate_formula().

code_shot(ascvd)

SELECT *, least(0.3, greatest(0.01, calculated_risk)) AS "estimated_risk"
FROM (
  SELECT
    *,
    (1 - baseline_survival) * exp(individual_sum - group_mean) AS "calculated_risk"
  FROM (
    SELECT
      *,
      case when is_woman then (
    case when is_black then 86.61
    else -29.18
    end)
  else (
    case when is_black then 19.54
    else 61.18
    end)
  end AS "group_mean"
    FROM (
      SELECT
        *,
        case when is_woman then (
    case when is_black then 0.9533
    else 0.9665
    end)
  else (
    case when is_black then 0.8954
    else 0.9144
    end)
  end AS "baseline_survival"
      FROM (
        SELECT
          *,
          case when is_woman then (
    case when is_black then (17.114 * ln(age) + 0.940 * ln(tc_value_as_number) + -18.920 * ln(hdl_value_as_number) + 4.475 * ln(age) * ln(hdl_value_as_number) + case when htt is true then
    29.291 * ln(sbp_value_as_number) else 0 end + case when htt is true then
    -6.432 * ln(age) * ln(sbp_value_as_number) else 0 end + case when htt is false then
    27.820 * ln(sbp_value_as_number) else 0 end + case when htt is false then
    -6.087 * ln(age) * ln(sbp_value_as_number) else 0 end + 0.691 * case when is_smoker then 1 else 0 end + 0.874 * case when has_diabetes then 1 else 0 end)
    else (-29.799 * ln(age) + 4.884 * ln(age)^2 + 13.540 * ln(tc_value_as_number) + -3.114 * ln(age) * ln(tc_value_as_number) + -13.578 * ln(hdl_value_as_number) + 3.149 * ln(age) * ln(hdl_value_as_number) + case when htt is true then
    2.019 * ln(sbp_value_as_number) else 0 end + case when htt is false then
    1.957 * ln(sbp_value_as_number) else 0 end + 7.574 * case when is_smoker then 1 else 0 end + -1.665 * ln(age) * case when is_smoker then 1 else 0 end + 0.661 * case when has_diabetes then 1 else 0 end)
    end)
  else (
    case when is_black then (2.469 * ln(age) + 0.30 * ln(tc_value_as_number) + -0.307 * ln(hdl_value_as_number) + case when htt is true then
    1.916 * ln(sbp_value_as_number) else 0 end + case when htt is false then
    1.809 * ln(sbp_value_as_number) else 0 end + 0.549 * case when is_smoker then 1 else 0 end + 0.645 * case when has_diabetes then 1 else 0 end)
    else (12.344 * ln(age) + 11.853 * ln(tc_value_as_number) + -2.664 * ln(age) * ln(tc_value_as_number) + -7.990 * ln(hdl_value_as_number) + 1.769 * ln(age) * ln(hdl_value_as_number) + case when htt is true then 
    1.797 * ln(sbp_value_as_number) else 0 end + case when htt is false then
    1.764 * ln(sbp_value_as_number) else 0 end + 7.837 * case when is_smoker then 1 else 0 end + -1.795 * ln(age) * case when is_smoker then 1 else 0 end + 0.658 * case when has_diabetes then 1 else 0 end)
    end)
  end AS "individual_sum"
        FROM (
          SELECT
            *,
            htt_drug_exposure_start_datetime is not null
      and htt_sbp_dist < '4 months' AS "htt"
          FROM (
            SELECT
              "row_id",
              "pid",
              "ts",
              "window",
              "person_gender_concept_id",
              "person_race_concept_id",
              "person_birth_datetime",
              "smoker_observation_datetime",
              "diabetes_condition_start_datetime",
              "htt_drug_exposure_start_datetime",
              "sbp_measurement_datetime",
              "tc_value_as_number",
              "hdl_value_as_number",
              "sbp_value_as_number",
              "diabetes_condition_concept_id",
              "htt_drug_concept_id",
              person_gender_concept_id = 8532 AS "is_woman",
              person_race_concept_id = 8516 AS "is_black",
              extract(year from age(ts, person_birth_datetime)) AS "age",
              smoker_observation_datetime is null AS "is_smoker",
              diabetes_condition_start_datetime is null AS "has_diabetes",
              case when htt_drug_exposure_start_datetime - sbp_measurement_datetime < interval '0'
        then sbp_measurement_datetime - htt_drug_exposure_start_datetime
        else htt_drug_exposure_start_datetime - sbp_measurement_datetime end AS "htt_sbp_dist"
            FROM (
              SELECT
                *,
                "ts" - least(sbp_ts, tc_ts, hdl_ts, smoker_ts, htt_ts) AS "window",
                last_value(row_id) over (partition by "pid", "ts") AS "ts_row"
              FROM (
                SELECT
                  "row_id",
                  "pid",
                  "ts",
                  MAX("sbp_measurement_datetime") OVER (PARTITION BY "pid", "..dbplyr_partion_1") AS "sbp_measurement_datetime",
                  MAX("sbp_value_as_number") OVER (PARTITION BY "pid", "..dbplyr_partion_2") AS "sbp_value_as_number",
                  MAX("sbp_ts") OVER (PARTITION BY "pid", "..dbplyr_partion_3") AS "sbp_ts",
                  MAX("dbp_ts") OVER (PARTITION BY "pid", "..dbplyr_partion_4") AS "dbp_ts",
                  MAX("tc_value_as_number") OVER (PARTITION BY "pid", "..dbplyr_partion_5") AS "tc_value_as_number",
                  MAX("tc_ts") OVER (PARTITION BY "pid", "..dbplyr_partion_6") AS "tc_ts",
                  MAX("hdl_value_as_number") OVER (PARTITION BY "pid", "..dbplyr_partion_7") AS "hdl_value_as_number",
                  MAX("hdl_ts") OVER (PARTITION BY "pid", "..dbplyr_partion_8") AS "hdl_ts",
                  MAX("ldl_ts") OVER (PARTITION BY "pid", "..dbplyr_partion_9") AS "ldl_ts",
                  MAX("diabetes_condition_concept_id") OVER (PARTITION BY "pid", "..dbplyr_partion_10") AS "diabetes_condition_concept_id",
                  MAX("diabetes_condition_start_datetime") OVER (PARTITION BY "pid", "..dbplyr_partion_11") AS "diabetes_condition_start_datetime",
                  MAX("diabetes_ts") OVER (PARTITION BY "pid", "..dbplyr_partion_12") AS "diabetes_ts",
                  MAX("smoker_observation_datetime") OVER (PARTITION BY "pid", "..dbplyr_partion_13") AS "smoker_observation_datetime",
                  MAX("smoker_ts") OVER (PARTITION BY "pid", "..dbplyr_partion_14") AS "smoker_ts",
                  MAX("htt_drug_concept_id") OVER (PARTITION BY "pid", "..dbplyr_partion_15") AS "htt_drug_concept_id",
                  MAX("htt_drug_exposure_start_datetime") OVER (PARTITION BY "pid", "..dbplyr_partion_16") AS "htt_drug_exposure_start_datetime",
                  MAX("htt_ts") OVER (PARTITION BY "pid", "..dbplyr_partion_17") AS "htt_ts",
                  MAX("person_gender_concept_id") OVER (PARTITION BY "pid", "..dbplyr_partion_18") AS "person_gender_concept_id",
                  MAX("person_birth_datetime") OVER (PARTITION BY "pid", "..dbplyr_partion_19") AS "person_birth_datetime",
                  MAX("person_race_concept_id") OVER (PARTITION BY "pid", "..dbplyr_partion_20") AS "person_race_concept_id",
                  MAX("person_ts") OVER (PARTITION BY "pid", "..dbplyr_partion_21") AS "person_ts"
                FROM (
                  SELECT
                    *,
                    SUM(CASE WHEN (("sbp_measurement_datetime" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_1",
                    SUM(CASE WHEN (("sbp_value_as_number" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_2",
                    SUM(CASE WHEN (("sbp_ts" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_3",
                    SUM(CASE WHEN (("dbp_ts" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_4",
                    SUM(CASE WHEN (("tc_value_as_number" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_5",
                    SUM(CASE WHEN (("tc_ts" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_6",
                    SUM(CASE WHEN (("hdl_value_as_number" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_7",
                    SUM(CASE WHEN (("hdl_ts" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_8",
                    SUM(CASE WHEN (("ldl_ts" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_9",
                    SUM(CASE WHEN (("diabetes_condition_concept_id" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_10",
                    SUM(CASE WHEN (("diabetes_condition_start_datetime" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_11",
                    SUM(CASE WHEN (("diabetes_ts" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_12",
                    SUM(CASE WHEN (("smoker_observation_datetime" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_13",
                    SUM(CASE WHEN (("smoker_ts" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_14",
                    SUM(CASE WHEN (("htt_drug_concept_id" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_15",
                    SUM(CASE WHEN (("htt_drug_exposure_start_datetime" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_16",
                    SUM(CASE WHEN (("htt_ts" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_17",
                    SUM(CASE WHEN (("person_gender_concept_id" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_18",
                    SUM(CASE WHEN (("person_birth_datetime" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_19",
                    SUM(CASE WHEN (("person_race_concept_id" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_20",
                    SUM(CASE WHEN (("person_ts" IS NULL)) THEN 0 ELSE 1 END) OVER (PARTITION BY "pid" ORDER BY "pid", "ts" ROWS UNBOUNDED PRECEDING) AS "..dbplyr_partion_21"
                  FROM (
                    SELECT
                      row_number() over () AS "row_id",
                      "pid",
                      "ts",
                      last_value(case when "name" = 'xbhjz5lfkgw2' then "measurement_datetime" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "sbp_measurement_datetime",
                      last_value(case when "name" = 'xbhjz5lfkgw2' then "value_as_number" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "sbp_value_as_number",
                      last_value(case when "name" = 'xbhjz5lfkgw2' then "ts" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "sbp_ts",
                      last_value(case when "name" = 'zkzbs6p13x9e' then "ts" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "dbp_ts",
                      last_value(case when "name" = 'l5rihbkl7yx1' then "value_as_number" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "tc_value_as_number",
                      last_value(case when "name" = 'l5rihbkl7yx1' then "ts" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "tc_ts",
                      last_value(case when "name" = 'ameqbwsx20ji' then "value_as_number" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "hdl_value_as_number",
                      last_value(case when "name" = 'ameqbwsx20ji' then "ts" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "hdl_ts",
                      last_value(case when "name" = 'nzoudrc9w6g0' then "ts" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "ldl_ts",
                      last_value(case when "name" = 'n4bedopnaz3h' then "condition_concept_id" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "diabetes_condition_concept_id",
                      last_value(case when "name" = 'n4bedopnaz3h' then "condition_start_datetime" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "diabetes_condition_start_datetime",
                      last_value(case when "name" = 'n4bedopnaz3h' then "ts" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "diabetes_ts",
                      last_value(case when "name" = 'mlpw4atk7f32' then "observation_datetime" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "smoker_observation_datetime",
                      last_value(case when "name" = 'mlpw4atk7f32' then "ts" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "smoker_ts",
                      last_value(case when "name" = 'nu6f2z0i43l7' then "drug_concept_id" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "htt_drug_concept_id",
                      last_value(case when "name" = 'nu6f2z0i43l7' then "drug_exposure_start_datetime" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "htt_drug_exposure_start_datetime",
                      last_value(case when "name" = 'nu6f2z0i43l7' then "ts" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "htt_ts",
                      last_value(case when "name" = 'anuhdibc93so' then "gender_concept_id" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "person_gender_concept_id",
                      last_value(case when "name" = 'anuhdibc93so' then "birth_datetime" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "person_birth_datetime",
                      last_value(case when "name" = 'anuhdibc93so' then "race_concept_id" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "person_race_concept_id",
                      last_value(case when "name" = 'anuhdibc93so' then "ts" else null end) over (partition by "pid", "name" order by "ts" rows between unbounded preceding and 0 preceding) AS "person_ts"
                    FROM (
                      (
                        SELECT
                          *,
                          NULL AS "gender_concept_id",
                          NULL AS "birth_datetime",
                          NULL AS "race_concept_id"
                        FROM (
                          (
                            SELECT
                              *,
                              NULL AS "drug_concept_id",
                              NULL AS "drug_exposure_start_datetime"
                            FROM (
                              (
                                SELECT *, NULL AS "observation_datetime"
                                FROM (
                                  (
                                    SELECT
                                      *,
                                      NULL AS "condition_concept_id",
                                      NULL AS "condition_start_datetime"
                                    FROM (
                                      (
                                        (
                                          (
                                            (
                                              SELECT
                                                'xbhjz5lfkgw2' AS "name",
                                                "person_id" AS "pid",
                                                "measurement_datetime" AS "ts",
                                                "measurement_datetime",
                                                "value_as_number"
                                              FROM "cdm_new_york3"."measurement"
                                              WHERE ("measurement_concept_id" = 3004249.0)
                                            )
                                            UNION ALL
                                            (
                                              SELECT
                                                *,
                                                NULL AS "measurement_datetime",
                                                NULL AS "value_as_number"
                                              FROM (
                                                SELECT
                                                  'zkzbs6p13x9e' AS "name",
                                                  "person_id" AS "pid",
                                                  "measurement_datetime" AS "ts"
                                                FROM "cdm_new_york3"."measurement"
                                                WHERE ("measurement_concept_id" = 3012888.0)
                                              ) "q01"
                                            )
                                          )
                                          UNION ALL
                                          (
                                            SELECT
                                              "name",
                                              "pid",
                                              "ts",
                                              NULL AS "measurement_datetime",
                                              "value_as_number"
                                            FROM (
                                              SELECT
                                                'l5rihbkl7yx1' AS "name",
                                                "person_id" AS "pid",
                                                "measurement_datetime" AS "ts",
                                                "value_as_number"
                                              FROM "cdm_new_york3"."measurement"
                                              WHERE ("measurement_concept_id" = 3027114.0)
                                            ) "q02"
                                          )
                                        )
                                        UNION ALL
                                        (
                                          SELECT
                                            "name",
                                            "pid",
                                            "ts",
                                            NULL AS "measurement_datetime",
                                            "value_as_number"
                                          FROM (
                                            SELECT
                                              'ameqbwsx20ji' AS "name",
                                              "person_id" AS "pid",
                                              "measurement_datetime" AS "ts",
                                              "value_as_number"
                                            FROM "cdm_new_york3"."measurement"
                                            WHERE ("measurement_concept_id" = 3007070.0)
                                          ) "q03"
                                        )
                                      )
                                      UNION ALL
                                      (
                                        SELECT
                                          *,
                                          NULL AS "measurement_datetime",
                                          NULL AS "value_as_number"
                                        FROM (
                                          SELECT
                                            'nzoudrc9w6g0' AS "name",
                                            "person_id" AS "pid",
                                            "measurement_datetime" AS "ts"
                                          FROM "cdm_new_york3"."measurement"
                                          WHERE ("measurement_concept_id" = 3009966.0)
                                        ) "q04"
                                      )
                                    ) "q05"
                                  )
                                  UNION ALL
                                  (
                                    SELECT
                                      "name",
                                      "pid",
                                      "ts",
                                      NULL AS "measurement_datetime",
                                      NULL AS "value_as_number",
                                      "condition_concept_id",
                                      "condition_start_datetime"
                                    FROM (
                                      SELECT
                                        'n4bedopnaz3h' AS "name",
                                        "person_id" AS "pid",
                                        "condition_start_datetime" AS "ts",
                                        "condition_concept_id",
                                        "condition_start_datetime"
                                      FROM "cdm_new_york3"."condition_occurrence"
                                      WHERE ("condition_concept_id" = 201826.0)
                                    ) "q06"
                                  )
                                ) "q07"
                              )
                              UNION ALL
                              (
                                SELECT
                                  "name",
                                  "pid",
                                  "ts",
                                  NULL AS "measurement_datetime",
                                  NULL AS "value_as_number",
                                  NULL AS "condition_concept_id",
                                  NULL AS "condition_start_datetime",
                                  "observation_datetime"
                                FROM (
                                  SELECT
                                    'mlpw4atk7f32' AS "name",
                                    "person_id" AS "pid",
                                    "observation_datetime" AS "ts",
                                    "observation_datetime"
                                  FROM "cdm_new_york3"."observation"
                                  WHERE ("observation_concept_id" IN (42709996.0))
                                ) "q08"
                              )
                            ) "q09"
                          )
                          UNION ALL
                          (
                            SELECT
                              "name",
                              "pid",
                              "ts",
                              NULL AS "measurement_datetime",
                              NULL AS "value_as_number",
                              NULL AS "condition_concept_id",
                              NULL AS "condition_start_datetime",
                              NULL AS "observation_datetime",
                              "drug_concept_id",
                              "drug_exposure_start_datetime"
                            FROM (
                              SELECT
                                'nu6f2z0i43l7' AS "name",
                                "person_id" AS "pid",
                                "drug_exposure_start_datetime" AS "ts",
                                "drug_concept_id",
                                "drug_exposure_start_datetime"
                              FROM (
                                SELECT
                                  "drug_exposure_id",
                                  "person_id",
                                  "drug_concept_id",
                                  "drug_exposure_start_date",
                                  "drug_exposure_start_datetime",
                                  "drug_exposure_end_date",
                                  "drug_exposure_end_datetime",
                                  "verbatim_end_date",
                                  "drug_type_concept_id",
                                  "stop_reason",
                                  "refills",
                                  "quantity",
                                  "days_supply",
                                  "sig",
                                  "route_concept_id",
                                  "lot_number",
                                  "provider_id",
                                  "visit_occurrence_id",
                                  "visit_detail_id",
                                  "drug_source_value",
                                  "drug_source_concept_id",
                                  "route_source_value",
                                  "dose_unit_source_value"
                                FROM "cdm_new_york3"."drug_exposure" AS "LHS"
                                INNER JOIN (
                                  SELECT "descendant_concept_id"
                                  FROM (
                                    SELECT
                                      "ancestor_concept_id",
                                      "descendant_concept_id",
                                      "min_levels_of_separation",
                                      "max_levels_of_separation"
                                    FROM "cdm_new_york3"."concept_ancestor" AS "LHS"
                                    INNER JOIN (
                                      SELECT "concept_id"
                                      FROM "cdm_new_york3"."concept"
                                      WHERE ("concept_code" IN ('C02', 'C03', 'C07', 'C08', 'C09') AND "vocabulary_id" = 'ATC')
                                    ) "RHS"
                                      ON ("LHS"."ancestor_concept_id" = "RHS"."concept_id")
                                  ) "q10"
                                ) "RHS"
                                  ON ("LHS"."drug_concept_id" = "RHS"."descendant_concept_id")
                              ) "q11"
                            ) "q12"
                          )
                        ) "q13"
                      )
                      UNION ALL
                      (
                        SELECT
                          "name",
                          "pid",
                          "ts",
                          NULL AS "measurement_datetime",
                          NULL AS "value_as_number",
                          NULL AS "condition_concept_id",
                          NULL AS "condition_start_datetime",
                          NULL AS "observation_datetime",
                          NULL AS "drug_concept_id",
                          NULL AS "drug_exposure_start_datetime",
                          "gender_concept_id",
                          "birth_datetime",
                          "race_concept_id"
                        FROM (
                          SELECT
                            'anuhdibc93so' AS "name",
                            "person_id" AS "pid",
                            "birth_datetime" AS "ts",
                            "gender_concept_id",
                            "birth_datetime",
                            "race_concept_id"
                          FROM "cdm_new_york3"."person"
                        ) "q14"
                      )
                    ) "q15"
                  ) "q16"
                ) "q17"
              ) "q18"
            ) "q19"
            WHERE ("row_id" = "ts_row" AND sbp_ts is not null and dbp_ts is not null and tc_ts is not null and hdl_ts is not null and ldl_ts is not null and person_ts is not null)
          ) "q20"
        ) "q21"
      ) "q22"
    ) "q23"
  ) "q24"
) "q25"

Author contact

Fabrício Kury
2022/Dec/03
Be always welcome to reach me at fab@kury.dev.